Inflammatory dermatitis is actually linked to LPS

May 21, 2024 3:06 pm

Itchy skin, psoriasis and LPS derived from gut microbiota seems to be entirely different topics.

However, a recent scientific report from Nature Research shows that these elements are actually the missing link in inflammatory dermatitis in patients with IBS.

Chronic stress is a major cause of irritable bowel syndrome (IBS), leading to increased intestinal epithelial permeability. Patients with IBS often experience comorbidities related to allergic skin diseases, such as atopic dermatitis (AD), psoriasis, and rosacea.

LPS can travel through the damaged colon epithelial barrier and activate peripheral TLR4 signaling, inducing skin itchiness. These discoveries emphasize the need to better understand LPS derived from gut microbiota.

This opens new doors for innovative treatments targeting gut-derived LPS, offering hope for improved management of inflammatory skin conditions in IBS patients.

Read more about the link between LPS and inflammatory dermatitis

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