Purified LipoPolySaccharides endotoxins TLR4 agonists
Endotoxins, also known as Lipopolysaccharides (LPS), are the major glycolipids of most Gram-negative bacterial outer membranes. LPS molecules forming the outer layer of this membrane represent about 50% of its weight and cover about 75% of the bacterial surface. LPS molecules are highly immunogenic. While the polysaccharide moiety carries the antigenic determinants (O-chains or core side chains), the lipid A portion is recognized by the innate immune cell receptors (TLR4-MD2-CD14 complex of macrophages and dendritic cells), leading to the activation of signalling cascades and resulting in the secretion of pro- (and anti-) inflammatory cytokines, thereby initiating inflammatory and immune defense responses. Endotoxin concentrations in the order of pg/ml are detected by cells of the human and animal immune systems.
We use our proprietary method without phenol to extract Lipopolysaccharides (LPS) from Gram-negative bacteria.We are able to provide you with ultra pure LPS thanks to our unique extraction method, which can be adapted to your expectations.
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LPS from Bordetella pertussis – UltraPure Grade
Naturally occurring short LPS, called LipoOligoSaccharide (LOS), isolated and purified from a Bordetella pertussis strain by LPS-BioSciences extraction method, purified and lyophized in powder form. Proteins content and Nucleic Acids content < 1 %, with hTLR2/hTLR4 positive response, and Lipid A structure data.
REFERENCE 2020014UNIT SIZE 100ugPRICE 200,00 € -
LPS from Salmonella Typhimurium LT2 Ra – UltraPure Grade
Rough type LPS isolated and purified from Salmonella enterica serovar Typhimurium – mutant Ra – strain by LPS-BioSciences extraction method, purified and lyophilized in powder form. Proteins and Nucleic Acids content < 2 %, with hTLR2/hTLR4 positive response, and Lipid A structure data.
REFERENCE 2020013UNIT SIZE 100ugPRICE 200,00 € -
LPS from E. coli O157:H7 – UltraPure Grade
Smooth type LPS isolated and purified from Escherichia coli O157:H7 strain by LPS-BioSciences extraction method, purified and lyophilized in powder form. Proteins content and Nucleic Acids content < 2 % with hTLR2/hTLR4 positive response, and Lipid A structure data.
REFERENCE 2020012UNIT SIZE 100ugPRICE 200,00 € -
LPS from E. coli O157:H7 – Pure Grade
Smooth type LPS isolated and purified from Escherichia coli O157:H7 strain by LPS-BioSciences extraction method, purified and lyophilized in powder form. Proteins content and Nucleic Acids content < 3 %, and Lipid A structure data.
REFERENCE 2020071UNIT SIZE 100ugPRICE 150,00 €