Martine CAROFF, DrSc,  Founder and CSO


Martine is president of the Board and the head of scientific research operations. 

Martine defended her Dr. ès Sciences thesis in Paris Sud University followed by a one year post-doctoral stay in the Immunochemistry Department of the National Research Council (NRC) in Ottawa, Canada.

As Director of the ESA “Endotoxins, Structures and Activities” group she is a Director at the French National Centre for Research (CNRS) and was also Head of a CNRS Group of Research. As a mass spectrometry specialist, she obtained the first spectra of native LPSs. One of her techniques for a new LPS extraction method is patented and was the basis of the R&D project that led to the creation of LPS-BioSciences. She was a recipient of the Paris Sud University Prize for Innovation and Valorisation in 2006, and was a laureate of the National Emergence Competition for innovative start-up projects in 2008 and for start-up creation in 2011. She has authored 111 publications in international journals, and 2 patents. She is a scientific councilor for the International Endotoxin and Innate Immunity Society (2010-2014).




Pr. Jean-Marc CAVAILLON, Co-founder and Expert in Innate Immunity


Jean-Marc is Board member and advisor for the immunology research operations. 

Jean-Marc was President of the "International Endotoxin and Innate Immunity Society” (1998-2000) of which he was a founding member. He has also an extensive expertise on cytokines, inflammation, and innate immunity. He initiated his biomedical research some twenty five years ago, particularly in the field of sepsis and systemic inflammation. He wrote the first book in French on cytokines (1993, 1996), and co-authored a book entitled "Sepsis and non-infectious inflammation: from biology to critical care " (2008).

Jean-Marc Cavaillon obtained his Doctorate in Science (Dr.Sc) in immunology from Paris VI University. After his post-doctoral training at the University of Toronto (Canada), he joined the Institut Pasteur where he made his entire career. He was Director of the course on General Immunology at the Institut Pasteur (1997-2002), Scientific Director of the “Euroconference" (2003-2006), and Director of the department “Infection and Epidemiology” (2006-2009). He is now chairing the Evaluation Committee of the Scientific Staff (2012-2013).

He is involved in many international immunology courses. He is a member of the Editorial Boards of several journals including “Innate Immunity” (former “Journal of Endotoxin Research"), “Shock”, and “Journal of Infectious Diseases”, and has been Associate-Editor of "Cytokine" (2002-2009). Pr. Jean-Marc Cavaillon has published 140 scientific articles, 73 reviews and 43 chapters in books on infection, innate immunity and septic shock.








Frederic CAROFF, MSc, MSBA, Co-founder and CEO


Frederic is in charge of Strategy, Management and Business Development.

Frederic is a repeat industrial manager with commercial entrepreneurship training. He holds a MSc from Ecole Centrale Paris in 2004 specialized in Industrial Management. He practiced "Lean Manufacturing" working with companies like Bouygues TP in Germany (2002), Gaz de France (2004), PSA Peugeot Citroen (2005-2012). During 8 years, he built a strong experience in Team and Project Management. Repeat manager of manufacturing teams up to 100 people, he was responsible for the industrial and manufacturing scale up of 10 projects that were launched on the market. 

After creating LPS-BioSciences, he completed his training at HEC Business School in 2012 with the Challenge plus program and during a specialized MBA in Entrepreneurship at ESSEC Business school in 2013, where he obtained his degree summa cum laude. 






Alexey NOVIKOV, PhD,  R&D Manager


Alexey is the Research and Development Manager, and he is in charge of the Adjuvant Project.

Along his professional life he developed a multidisciplinary expertise in Chemistry (Chem. Engineer, Leningrad Institute of Technology, 1989), Physics (PhD, Radium Institute, St. Petersburg, 1996) and Biochemistry (HDR, Paris-Sud University, 2009). His PhD thesis on nano-cluster beams was followed by post-doctoral trainings at Uppsala University, Technical University Darmstadt and the Institutes of Nuclear Physics in Orsay and Lyon, progressively bringing him to analytical applications of nano-particles and mass-spectrometry in Biochemistry. As a member of the ESA “Endotoxins, Structures and Activities” group (2004-2011), he brought an important contribution to the studies of structural diversity and variability of endotoxins related to bacterial adaptation and virulence. He is a co-author of 40 articles published in international journals and 2 patents.




Stéphanie THEBAULT, PhD,  Operations Manager


Stéphanie is in charge of the Research Service activity of LPS-Biosciences.

She holds a MSc from Chimie ParisTech (2009) and she defended her doctoral thesis in Biochemistry at the Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA, ENS Cachan, France) in collaboration with the Structural Biology department of the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) of Strasbourg (2009-2013, France). During her PhD, she specialized in the study of apoptotic protein complexes. After working as an R&D engineer in the animal diagnostic department of Thermofisher (2014, Lyon, France), she joined LPS-Biosciences as Operations Manager.





Flavien DARDELLE, PhD, Diagnostic Manager – BACTI-DIAG Project Manager.


Flavien is in charge of the Diagnostic activity of LPS-BioSciences.

Flavien has a PhD in Cell Biology from the University of Rouen (France, 2008-2011). He specialized in extraction and analysis of complex plant carbohydrates. He followed his education with two post-doctoral contracts, working on glycosylated proteins (2011-2012, University of Rouen) in agreement with the Universities of Madrid (Spain) and Munster (Germany), then working on microalgae polysaccharides for cosmetic and food processing industries (2013-2014, Fitoplancton Marino, Spain) in agreement with the University  of Athens (Greece), a CNRS laboratory (Grenoble, France) and a cosmetic company (Greece). He arrived at LPS-Biosciences in January 2015 as BACTI-DIAG Project Manager.










Pr. Nicole GUISO, Expert in infectious diseases vaccines and Whooping cough.


Nicole is Scientific President of the Perilic Project, former Director of Research at Institut PASTEUR, Director of two national centers of reference of vaccine preventable diseases. 

Nicole Guiso is the Head of the Research Unit, Molecular Prevention and Therapy of Human Diseases, and Director of the 'National Whooping cough and other Bordetelloses Reference Centre' and of the 'Toxinogenic Corynebacteria Reference Centre' at the Institut Pasteur in Paris, France. She joined Institut Pasteur in 1972 as a voluntary trainee, having obtained a Master's Degree in biochemistry.

In 1980, Nicole Guiso was awarded a PhD for her thesis on the evolution of the lactose genes in Enterobacteriaceae. Nicole Guiso left the Pasteur Institute to study Archaebacteria as Visiting Lecturer at the National Jewish Hospital in Denver, Colorado, USA. She returned to the Institute in 1988, resuming the post of Research Lecturer, undertaking studies on the factors implicated in Bordetella species pathogenicity.

In 1991, Nicole Guiso was appointed Laboratory Head and, 2 years later, she became Director of the National Bordetella Reference Centre and the Head of the Bordetella Research Unit. Professor Guiso accepted the position of Head of the Ecosystems and Epidemiology of Infectious Diseases department in 2002 and, in 2008, became Head of the Toxigenic Corynebacteria Reference Centre.

Nicole Guiso was awarded the Nicloux Prize of the French Chemical Society in 1984, the Dr Darolles Prize of the Academy of Medicine in 1998, and received the 'Grade de Chevalier dans l'ordre National du Mérite' in 2001 and the French Legion of Honor Medal in 2006. 




Pr. Charles DUMONTET, Expert in Hematology and Oncology


Charles is Professor of Hematology in University of Lyon Deputy Director CRCL Senior Physician in Hematology.

Charles is an M.D. Ph.D. with specializations in internal medicine, oncology and hematology. After a 2 years post doctoral fellowship in Stanford Medical School he created his research team and is now P.I. of a team within the Cancer Research Center of Lyon dedicated to oncopharmacology.  He has performed animal experimentation for over 20 years and conducted a variety of translational research projects in hematology and solid tumors. He also teaches hematology for medical students and coordinates a master’s program in cancer research at the University Claude Bernard Lyon 1. He is deputy director of the Cancer Research Center of Lyon, of the translational research program LYRIC (coordinator Pr Jean Yves Blay) and of the Fédération Hospitalo-Universitaire DIPOHL (directeur Pr Gilles Salles, HCL). He is the chair of the Hospices Civils de Lyon Research Council.

He is the head of the Anticancer Antibodies team, composed by medical doctors, post-docs, students and technicians, possess and expertise in the field of preclinical in vitro and in vivo modeling, as well as in the identification and the validation of predictive or prognostic factors in clinical samples and the development of new compounds or new therapeutic strategies. Our work is focused on monoclonal antibodies used in the treatment of hematological malignancies or breast cancer. They explore the nature and the role of effector cells implicated in the antitumor activity of these monoclonal antibodies, in addition to the role of the cells of the microenvironment such as adipocytes. We also search for new apoptotic signaling pathways induced by antibodies in the cancer cells, we develop new strategies for sensitization of cancer cells to monoclonal antibodies, and we evaluate the clinical relevance of observations made in preclinical models.



Yves COMBARNOUS, PhD, Expert in Reproductive Physiology and Molecular Endocrinology


Yves is Director of Research at the French National Centre for Research (CNRS).

He obtained his PhD in Biological Chemistry in Liège, Belgium. He has focused his research on the Structure-Function relationships of Glycoprotein Hormones involved in Reproduction. He is currently heading a research group at the National Institute for Agricultural Research (INRA) in Nouzilly where he was Head of an INRA-CNRS Unit of 140 people. He also headed a Distribution Center of Transgenic Animals (CDTA-CNRS) in Orleans for five years (2001-2005).

He is a Member and Scientific Secretary of the "Development-Reproduction-Evolution-Stem Cells"  (2008-2012) panel of the CNRS National Comity and has authored more than 100 publications in international journals, 1 patent and three books about hormone structures and cell signaling.





Pr. Marc G.J. FEUILLOLEY, Expert in Pathogen - Host interactions


Marc defended a PhD and “Habilitation to Direction of Research” in an INSERM laboratory of the University of Rouen (France). He joined the CHU Laval (Quebec, Canada) for two post-doctoral stays and was recruited as Assistant Professor at the University of Rouen in 1988. Promoted as full Professor in 1997, he created a team working on Cellular Microbiology (eukaryote-bacteria communication). Pr. Feuilloley is now Director of the Laboratory of Microbiology Signals and Microenvironment (LMSM EA4312) of the University of Rouen. Within the same time, from 2006 to 2011 he was also Director of the technology transfer organism ADIPpharm and in 2012, he founded BioAdmetys SAS with two partners. Initially specialized in Cell Biology and Microbiology, Pr. Feuilloley also developed an interest in In Vitro Toxicology and more specifically in content-containers interactions, working as an expert for French Agencies (ANR, AERES, AFSSET), Romanian Agencies (NURC, NASR), Health & Environment Canada, and private societies. Pr. Feuilloley is also a member of the Direction Boards of technological platform (PFT) Normandie Sécurité Sanitaire and of the Technopole Chimie-Biologie-Santé (Région Haute-Normandie), of the Scientific Board of the Pôle de Compétitivité Cosmetic-Valley (first world pôle de compétitivité in cosmetics) and Member of the Conseil National des Universités  (CNU65). Pr. Feuilloley is the author of 98 articles and 29 abstracts published in international peered reviewed journals, 9 reviews or book chapters, 1 patent and more than 200 oral and poster communications in national and international congresses.