Come and listen to our talk with Charles River on LER issues.
Meet Martine and Flavien to discuss on the latest solutions for endotoxins detection and removal.
Come and meet us at the 17th Congress of European Shock Society, Paris, September 13-15, 2017.
LPS-BIOSCIENCES will be attending the poster session with a poster presenting a comparison of the various endotoxins detection and quantification methods used in sepsis studies.
Serge Della Negra presented Andromede in Krakov, Polland during an oral presentation.
The Andromede project (ANR-10-EQPX-23) is a new instrument for surface modification, analysis and ionic imaging mass spectrometry using the impact of ions in the MeV range.
LPS-BIOSCIENCES is part of the project partners to explore the possibility of analyzing natural occurring endotoxins structures directly from membranes surfaces thanks to this new tool.
SEITE, Sophie, BRETON, Aude, NOVIKOV, Alexey, et al. all bacteria lipopolysaccharides are not endotoxins: Structure to activity relationships: vitreoscilla filiformis example. Journal of the American Academy of Dermatology, 2017, vol. 76, no 6, p. AB36.
Introduction: Endotoxins are the main components of the outer membrane of Gram-negative bacteria. Each bacterium possesses a specific lipopolysaccharides (LPS) structure. Chemically, endotoxins are LPS, but not all LPS are endotoxins. They are composed of two moieties: the polysaccharidic (PS) and the lipid A. The PS moiety is made of the so-called O-antigens linked to core oligosaccharides. They carry the antigenic properties of the molecule and can be used in vaccines as well as in bacterial detection tests. As an example, we studied Vitreoscilla filiformis, a Gram-negative bacterium isolated from spa waters and chosen for its beneficial effects on atopic dermatitis lesions.