More than a century ago, Elie Metchnikoff established the bases of cellular innate immunity when he discovered the mechanism of phagocytosis.
However, during most of the XXth century, adaptive immunity (also known as specific immunity) focused most of the interest of the researchers, until Emile Janeway and Polly Matzinger revisited the definition of immunology. What was called “non-specific immunity” was renamed “innate immunity”, and the understanding of the sensing of the exogenous or endogenous dangers signals, and their identification revolutionized our understanding of the early mechanism aimed to defend the integrity of the host against any type of attacks including pathogens.
Nowadays, how bacteria, viruses, parasites and fungi are sensed by the infected host, have been mostly deciphered. Similarly, the mechanisms of the host involved to defend its integrity against infectious process have been decoded. This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens.
Please follow the Link: https://www.fun-mooc.fr/courses/course-v1:pasteur+96004+session01/about